ASTCT Practice Guidelines2.5.1

ASTCT practice guidelines and clinical calculators for blood and bone marrow transplantation, and cellular therapies.

The ASTCT Practice Guidelines application provides up to date access to practice guidelines, evidence-based reviews and position statements from the ASTCT Committee on Practice Guidelines. These documents are developed and updated by leading experts in the field of blood and bone marrow transplantation and cellular therapy. In addition the app includes clinical calculators relevant to HCT patients. These tools will allow immediate access to information that can help guide clinical decision making.

Topics covered include:

. General guidelines
. Conditioning regimens
. Stem cell collection and mobilization
. Graft-Versus-Host disease
. HCT for Malignant and non-Malignant Hematologic Diseases, including pediatric and adult patients
. Supportive Care
. Survivorship

Detailed references and full access to source papers is also provided.

The American Society for Transplantation and Cellular Therapy (ASTCT) is an international professional membership association of physicians, investigators and other health care professionals, dedicated to improving the application and success of blood and marrow transplantation and related cellular therapies.

Version History • Fixed a bug where a form field only allowed numeric input 2.5.1 Sep 16 • New guidelines 2.5.0 Sep 12 • Bugfixes and improvements 2.4.1 Jun 10 • New Guideline: Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy
• New Calculator: TA-TMA Diagnostic and Risk Stratification
• Updated Resources
• Bugfixes and improvements 2.4.0 Apr 24 • New Guidelines 2.3.0 Mar 6 • Several new Guidelines. See the "Latest Updates" section on the home screen. 2.2.0 12/02/2025 • New/Updated guidelines and calculators 2.1.0 09/04/2025 • Bugfixes and improvements 2.0.3 07/28/2025 • Bug fixes and improvements 2.0.2 04/30/2025 • bug fixes 2.0.1 04/29/2025 - We've rebuilt the app from the ground up for a better user experience!
- Better searching and filtering to find content more quickly.
- New tools for diagnosing and scoring GVHD. 2.0.0 04/25/2025 • Minor content updates 1.25.0 08/08/2024 • Bug fixes 1.24.0 03/05/2024 New Guidelines:
• Return to Work Guidance Committee Recommendations for Health Care Providers Who Take Care of Hematopoietic Cell Transplantation Patients
• Series, #6: Management of Invasive Candidiasis in Hematopoietic Cell Transplantation Recipients
• Evaluation of Children with Malignancies for Blood and Marrow Transplantation: A Report from the ASTCT Committee on Practice Guidelines 1.23.0 12/15/2023 • We've added a quick survey to help us improve the app. We value your feedback! 1.22.0 10/26/2023 • Minor updates 1.21.1 09/10/2023 • New guideline: Immune Effector Cell-Associated Hemophagocytic Lymphohistiocytosis-Like Syndrome
• New guideline: ASTCT Clinical Practice Recommendations for Transplantation and Cellular Therapies in Multiple Myeloma
• New guideline: Revised Guidelines for Coronavirus Disease 19 Management in Hematopoietic Cell Transplantation and Cellular Therapy Recipients
• New guideline: Hematopoietic Cell Transplantation in the Management of Myelodysplastic Syndrome: An Evidence-Based Review from the American Society for Transplantation and Cellular Therapy Committee on Practice Guidelines
• fix for certain buttons not displaying in iOS 16 1.21.0 08/09/2023 • Fixed bug with home screen not displaying correctly on newest iOS 1.20.1 07/31/2023 • Three new Practice Guidelines 1.20.0 12/10/2022 New Guidelines:

• American Society of Transplantation and Cellular Therapy Series, 1: Enterobacterales Infection Prevention and Management after Hematopoietic Cell Transplantation
• Guidelines for Cord Blood Unit Selection
• Guidelines for Cord Blood Unit Thaw and Infusion
• Hematopoietic Cell Transplantation in the Treatment of Newly Diagnosed Adult Acute Myeloid Leukemia: An Evidence-Based Review from the American Society of Transplantation and Cellular Therapy 1.19.0 11/15/2022 New Guideline: Guidelines for Pediatric Unrelated Cord Blood Transplantation—Unique Considerations 1.18.0 07/21/2022 • Guideline: American Society of Transplantation and Cellular Therapy Series, 2: Management and Prevention of Aspergillosis in Hematopoietic Cell Transplantation Recipients
• Guideline: Guidelines for Adult Patient Selection and Conditioning Regimens in Cord Blood Transplant Recipients with Hematologic Malignancies and Aplastic Anemia
• Guideline: Standardizing Definitions of Hematopoietic Recovery, Graft Rejection, Graft Failure, Poor Graft Function, and Donor Chimerism in Allogeneic Hematopoietic Cell Transplantation: A Report on Behalf of the American Society for Transplantation and Cellular Therapy
• Latest Timing Guidelines 1.17.0 05/26/2022 New paper: American Society of Transplantation and Cellular Therapy, Center of International Blood and Marrow Transplant Research, and European Society for Blood and Marrow Transplantation Clinical Practice Recommendations for Transplantation and Cellular Therapies in Mantle Cell Lymphoma 1.15.0 01/25/2022 • New calculator: Simplified Comorbidity Index (SCI)
• New paper: Guidelines for Infection Prophylaxis, Monitoring and Therapy in Cord Blood Transplantation
• New paper: Guidelines for the Prevention and Management of Graft-versus-Host Disease after Cord Blood Transplantation
• Updated presentation: CAR T Therapy 1.14.0 12/08/2021 • New guideline: Preventing Measles in Immunosuppressed Cancer and Hematopoietic Cell Transplantation Patients 1.13.0 07/01/2021